3. And they are usually taken until the symptoms are gone. Dida in Fleming Island, FL. Which is better for poison ivy, Claratin or Benadryl (diphenhydramine)? Sept. And they are usually taken until the symptoms are gone. Taking Benadryl at nighttime will make most people drowsy and help them sleep through the night without itching. Mental symptoms may include confusion, mood swings, a heightened Cheap Lipitor 20 Mg sense of well being, nervousness, and personality differences. Kids health & safety. Most cases of poison ivy go away on their own in 1 to 3 weeks. And the rash typically goes away on its own in two to three weeks. Is that okay? 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