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DESYREL (trazodone hydrochloride) tablets for oral administration contain trazodone hydrochloride, a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist. This information does not contain all possible interactions or adverse effects. Trazodone isn't approved for use in children younger than age 18. Data sources include IBM Watson Micromedex (updated 3 Mar 2022), Cerner Multum™ (updated 2 Viagra Money Order Mar 2022), ASHP (updated 17 Feb 2022. This drug was LIFE CHANGING, and I do not mean for the better. Trazodone has serious interactions with at least 151 other drugs. Multi ingredient medications may also be listed when applicable. Valhallahorseriding. Trazodone is an oral antidepressant drug that affects the chemical messengers (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other. 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