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While many people are prescribed prescription medications to treat their anxiety symptoms, some may turn to herbal alternatives to use in place of — or in addition to — other treatments Supplements include herbs as well as vitamins, minerals, and other ingredients. The 13 natural remedies below have been proven effective and safe, and may even help you reduce or eliminate the need for medication. A September 2018 review of 19 clinical. Eat Less Sugar. Other supplements to consider include B complex vitamins, chamomile, valerian, bacopa, ginkgo, ginseng, and oregano oil Natural Supplements for Anxiety When people are looking to treat their anxiety without medication, what they usually mean is that they want to know what herbs and supplements will work for them. If you suffer from depression or anxiety, life might seem overwhelming at times. John’s wort.