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I then tried Xanax, and the high which I got was incredible. 7 – Motion Sickness Pills. Drinking alcohol can increase certain side effects of Zoloft. When you use them correctly, they can prevent the sickness you may feel when on a boat or a plane.. S. Zoloft can cause a serious heart problem. The brain also produces endocannabinoids to induce feelings of pleasure and mitigate pain. Using these bath salts is occasionally fatal. It is worth noting that this drug may give a feeling of being lifted because of depression slowly going away but that is not exactly getting high. The motion sickness pills you purchase over the counter are antihistamines. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. No you can't get high off Zoloft. 2. Doctors your own question and get educational, text answers — it's anonymous and free! 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